Yes. Norfentanyl is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 8 ng/mL. It is a breakdown product of fentanyl. The LabX 12-panel screen includes a Fentanyl line, but how strongly a screen reacts to Norfentanyl varies, so a negative screen does not rule it out. Laboratory confirmation measures Norfentanyl specifically.
Norfentanyl is the main metabolite of fentanyl, produced when the liver breaks the drug down. It is not prescribed on its own.
Norfentanyl has no separate medical use; it reflects fentanyl that has been metabolized.
Because Norfentanyl comes from Fentanyl, the two are reported side by side and read together.
Norfentanyl is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Norfentanyl as detected when its concentration is at or above the cut-off of 8 ng/mL, within a reportable range of 8–400 ng/mL. It is one of 4 compounds in the fentanyl and novel opioids family on the 76-drug confirmation panel.
The laboratory's confirmation report lists an approximate detection window of 1-4 days for Norfentanyl. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.
The LabX 12-panel screen includes a Fentanyl line, but how strongly a screen reacts to Norfentanyl varies, so a negative screen does not rule it out. Laboratory confirmation measures Norfentanyl specifically.
Norfentanyl often remains measurable after fentanyl itself has fallen below the laboratory cut-off, so reporting both gives a more complete picture.
Fentanyl and its metabolite, plus the main alkaloids in kratom. These are not reliably found by general opiate screens, which is why confirmation measures them directly.
Yes. Norfentanyl is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 8 ng/mL. It is a breakdown product of fentanyl. The LabX 12-panel screen includes a Fentanyl line, but how strongly a screen reacts to Norfentanyl varies, so a negative screen does not rule it out. Laboratory confirmation measures Norfentanyl specifically.
LabX reports Norfentanyl as detected at or above 8 ng/mL, and the method's reportable range is 8–400 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.
The laboratory lists an approximate window of 1-4 days, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.
The LabX 12-panel screen includes a Fentanyl line, but how strongly a screen reacts to Norfentanyl varies, so a negative screen does not rule it out. Laboratory confirmation measures Norfentanyl specifically.
Norfentanyl has no separate medical use; it reflects fentanyl that has been metabolized.
Norfentanyl is a breakdown product of fentanyl. Laboratories measure it because it shows the parent drug was actually processed by the body.
Terms on this page: metabolite · cut-off · detection window · presumptive result · confirmation test. More questions: LabX answers.
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