Opioid treatment and reversal

Does a drug test detect Naloxone?

Yes. Naloxone is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 5 ng/mL. Naloxone is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

5 ng/mLLaboratory cut-off
5–500 ng/mLReportable range
LC-MS/MSConfirmation method

What is Naloxone?

Naloxone is an opioid antagonist: it blocks opioid receptors and can rapidly reverse the effects of an opioid overdose.

Also known as or found in: Narcan.

Medical use

Naloxone is used as an emergency overdose-reversal medicine, available as a nasal spray (including without a prescription) and by injection. It is also combined with buprenorphine in some treatment medicines.

How LabX tests for Naloxone

Naloxone is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Naloxone as detected when its concentration is at or above the cut-off of 5 ng/mL, within a reportable range of 5–500 ng/mL. It is one of 5 compounds in the opioid treatment and reversal family on the 76-drug confirmation panel.

Detection window

The laboratory's confirmation report does not print a standard detection window for Naloxone. How long any compound stays measurable varies with the amount taken, how often it is used, metabolism and hydration, and a laboratory result cannot be used to work out when a substance was taken.

Screen versus confirmation

Naloxone is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

Worth knowing

Finding naloxone on a report can reflect a combination treatment product or emergency use. It does not by itself indicate opioid use.

About this drug family

Medicines used to treat opioid and alcohol use disorder or to reverse an overdose, with their metabolites, as monitored in treatment programs.

Common questions

Does a drug test detect Naloxone?

Yes. Naloxone is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 5 ng/mL. Naloxone is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

What is the laboratory cut-off for Naloxone?

LabX reports Naloxone as detected at or above 5 ng/mL, and the method's reportable range is 5–500 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.

How long can Naloxone be detected?

The laboratory report does not print a standard window for Naloxone. Detection time varies with dose, frequency of use, metabolism and hydration.

Can a 12-panel drug screen detect Naloxone?

Naloxone is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

Is Naloxone a prescription medicine?

Naloxone is used as an emergency overdose-reversal medicine, available as a nasal spray (including without a prescription) and by injection. It is also combined with buprenorphine in some treatment medicines.

Related compounds

Terms on this page: metabolite Β· cut-off Β· detection window Β· presumptive result Β· confirmation test. More questions: LabX answers.

Test for Naloxone and 75 other compounds

12-panel urine $89 or fingerstick blood $99, plus the 76-drug LC-MS/MS confirmation for +$89.

At-home drug tests and test kits are not currently available to addresses in New York, New Jersey, Rhode Island or California. Results are not a diagnosis β€” review them with a licensed physician.

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Talk to a licensed physician. LabX Diagnostics and Vantage provide laboratory testing only. The information on this page is educational and is not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about test results, symptoms or medicines, and before making any health decision. If you think you may have a medical emergency, call 911. Read our medical disclaimer.

Medical disclaimer. LabX Diagnostics and Vantage provide laboratory testing only. Test results and information on this site are for informational purposes and are not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about your results and before making any health decision. If you think you may have a medical emergency, call 911. Read the full disclaimer.

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