Yes. 6β-naltrexol is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 10 ng/mL. It is a breakdown product of naltrexone. 6β-naltrexol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
6-beta-naltrexol is the main metabolite of naltrexone, formed in the liver. It is present at higher levels than naltrexone itself after a dose.
6-beta-naltrexol is not prescribed on its own; it reflects naltrexone that has been taken.
Because 6β-naltrexol comes from Naltrexone, the two are reported side by side and read together.
6β-naltrexol is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports 6β-naltrexol as detected when its concentration is at or above the cut-off of 10 ng/mL, within a reportable range of 10–6,000 ng/mL. It is one of 5 compounds in the opioid treatment and reversal family on the 76-drug confirmation panel.
The laboratory's confirmation report lists an approximate detection window of 4-6 hours for 6β-naltrexol. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.
6β-naltrexol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
Treatment programs that monitor naltrexone adherence often rely on this metabolite because it is the more abundant of the two compounds.
Medicines used to treat opioid and alcohol use disorder or to reverse an overdose, with their metabolites, as monitored in treatment programs.
Yes. 6β-naltrexol is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 10 ng/mL. It is a breakdown product of naltrexone. 6β-naltrexol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
LabX reports 6β-naltrexol as detected at or above 10 ng/mL, and the method's reportable range is 10–6,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.
The laboratory lists an approximate window of 4-6 hours, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.
6β-naltrexol is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.
6-beta-naltrexol is not prescribed on its own; it reflects naltrexone that has been taken.
6β-naltrexol is a breakdown product of naltrexone. Laboratories measure it because it shows the parent drug was actually processed by the body.
Terms on this page: metabolite · cut-off · detection window · presumptive result · confirmation test. More questions: LabX answers.
Test for 6β-naltrexol and 75 other compounds
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