Yes. Alpha-OH-alprazolam is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 30 ng/mL. It is a breakdown product of alprazolam (Xanax). The LabX 12-panel screen includes a Benzodiazepines line, but how strongly a screen reacts to Alpha-OH-alprazolam varies, so a negative screen does not rule it out. Laboratory confirmation measures Alpha-OH-alprazolam specifically.
Alpha-hydroxyalprazolam is the main metabolite of alprazolam, formed in the liver. It is not prescribed on its own.
Alpha-hydroxyalprazolam has no separate medical use; it reflects alprazolam that has been metabolized.
Because Alpha-OH-alprazolam comes from Alprazolam, the two are reported side by side and read together.
Alpha-OH-alprazolam is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Alpha-OH-alprazolam as detected when its concentration is at or above the cut-off of 30 ng/mL, within a reportable range of 30–3,000 ng/mL. It is one of 8 compounds in the benzodiazepines and z-drugs family on the 76-drug confirmation panel.
The laboratory's confirmation report lists an approximate detection window of 1-5 days for Alpha-OH-alprazolam. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.
The LabX 12-panel screen includes a Benzodiazepines line, but how strongly a screen reacts to Alpha-OH-alprazolam varies, so a negative screen does not rule it out. Laboratory confirmation measures Alpha-OH-alprazolam specifically.
Many benzodiazepines are excreted mostly as metabolites, so measuring alpha-hydroxyalprazolam helps a laboratory identify alprazolam that the parent-drug result alone might miss.
Prescription sedatives and sleep medicines and their metabolites. Standard screens detect individual benzodiazepines unevenly, so confirmation identifies each one.
Yes. Alpha-OH-alprazolam is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 30 ng/mL. It is a breakdown product of alprazolam (Xanax). The LabX 12-panel screen includes a Benzodiazepines line, but how strongly a screen reacts to Alpha-OH-alprazolam varies, so a negative screen does not rule it out. Laboratory confirmation measures Alpha-OH-alprazolam specifically.
LabX reports Alpha-OH-alprazolam as detected at or above 30 ng/mL, and the method's reportable range is 30–3,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.
The laboratory lists an approximate window of 1-5 days, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.
The LabX 12-panel screen includes a Benzodiazepines line, but how strongly a screen reacts to Alpha-OH-alprazolam varies, so a negative screen does not rule it out. Laboratory confirmation measures Alpha-OH-alprazolam specifically.
Alpha-hydroxyalprazolam has no separate medical use; it reflects alprazolam that has been metabolized.
Alpha-OH-alprazolam is a breakdown product of alprazolam (Xanax). Laboratories measure it because it shows the parent drug was actually processed by the body.
Terms on this page: metabolite · cut-off · detection window · presumptive result · confirmation test. More questions: LabX answers.
Test for Alpha-OH-alprazolam and 75 other compounds
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