Muscle relaxants, sedatives and analgesics

Does a drug test detect Acetaminophen?

Yes. Acetaminophen is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 500 ng/mL. Acetaminophen is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

500 ng/mLLaboratory cut-off
500–50,000 ng/mLReportable range
6-8 hoursApprox. window (varies)
LC-MS/MSConfirmation method

What is Acetaminophen?

Acetaminophen (paracetamol) is a pain reliever and fever reducer. It is sold over the counter and is also an ingredient in many combination prescription products.

Also known as or found in: Tylenol.

Medical use

Acetaminophen is used for pain and fever, and is combined with opioids such as hydrocodone, oxycodone and codeine, and with butalbital, in prescription products.

How LabX tests for Acetaminophen

Acetaminophen is measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS), which separates the compounds in a sample and identifies each one by its mass. That is different from a rapid screen, which reacts to a family of drugs and can occasionally react to a related substance. The laboratory reports Acetaminophen as detected when its concentration is at or above the cut-off of 500 ng/mL, within a reportable range of 500–50,000 ng/mL. It is one of 9 compounds in the muscle relaxants, sedatives and analgesics family on the 76-drug confirmation panel.

Detection window

The laboratory's confirmation report lists an approximate detection window of 6-8 hours for Acetaminophen. Treat that as a rough guide only: how long any compound stays measurable varies with the amount taken, how often it is used, body composition, metabolism, kidney and liver function, and hydration. A laboratory result cannot be used to work out when a substance was taken.

Screen versus confirmation

Acetaminophen is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

Worth knowing

Acetaminophen on a report is common and usually reflects ordinary use. Seeing it with an opioid can simply mean a combination product was taken.

About this drug family

Muscle relaxants, barbiturates, nerve-pain medicines and acetaminophen, several of which are monitored in pain management and treatment programs.

Common questions

Does a drug test detect Acetaminophen?

Yes. Acetaminophen is one of the 76 compounds in the LabX LC-MS/MS confirmation panel, reported as detected at or above 500 ng/mL. Acetaminophen is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

What is the laboratory cut-off for Acetaminophen?

LabX reports Acetaminophen as detected at or above 500 ng/mL, and the method's reportable range is 500–50,000 ng/mL. A result below the cut-off is reported as not detected; it does not prove none was present.

How long can Acetaminophen be detected?

The laboratory lists an approximate window of 6-8 hours, but it varies with dose, frequency of use, metabolism and hydration, and cannot be used to tell when something was taken.

Can a 12-panel drug screen detect Acetaminophen?

Acetaminophen is not one of the 12 lines on the LabX 12-panel screen. It is identified by adding laboratory confirmation, which tests for all 76 compounds on the panel.

Is Acetaminophen a prescription medicine?

Acetaminophen is used for pain and fever, and is combined with opioids such as hydrocodone, oxycodone and codeine, and with butalbital, in prescription products.

Related compounds

Terms on this page: metabolite Β· cut-off Β· detection window Β· presumptive result Β· confirmation test. More questions: LabX answers.

Test for Acetaminophen and 75 other compounds

12-panel urine $89 or fingerstick blood $99, plus the 76-drug LC-MS/MS confirmation for +$89.

At-home drug tests and test kits are not currently available to addresses in New York, New Jersey, Rhode Island or California. Results are not a diagnosis β€” review them with a licensed physician.

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Talk to a licensed physician. LabX Diagnostics and Vantage provide laboratory testing only. The information on this page is educational and is not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about test results, symptoms or medicines, and before making any health decision. If you think you may have a medical emergency, call 911. Read our medical disclaimer.

Medical disclaimer. LabX Diagnostics and Vantage provide laboratory testing only. Test results and information on this site are for informational purposes and are not medical advice, diagnosis or treatment. Always consult a licensed physician or other qualified healthcare provider about your results and before making any health decision. If you think you may have a medical emergency, call 911. Read the full disclaimer.

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